Types of switch

There are 4 kinds of ‘Therapeutic Switch’, or drug repurposing project:

Project type Issue
Compound on the market and still under original composition of matter patent protection Mainly for the original marketing company, hampered by a risk of adverse clinical findings damaging the market for the primary indication
Compound on the market, but off patent Risk of generic (‘off-label’) competition, alleviated by product differentation
Compound not fully developed for original indication Lower risk of competition from generic competition, greater risk of adverse toxicology, smaller patient safety database
Steroisomer or metabolite of an existing racemate Some preclinical development to be done, and need to differentiate from existing racemic drug